Copper (Cu) is an important trace element and is associated with a number of metalloproteins and it is a catalytic component of numerous enzymes and also a structural component of other important proteins. Copper is involved in many vital processes in the body, Energy Production, connective tissue formation, iron metabolism, melanin synthesis, Normal function of CNS, Regulation of gene expression and has Antioxidant function . Excess Cu ingestion interfere with absorbtion of zinc and can lead to Zinc deficiency, which is frequently characterized by slow healing, The classical presentation of Cu toxicosis is represented by the genetic disease of Cu accumulation known as Wilson's disease. This disease is typified by hepatocellular damage (increase transferase) and/or changes in mood and behavior because of accumulation of Cu in Central Neurons.